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PNA FISH ProbesPNA FISH probes hybridize to target DNA with high sensitivity and specificity mainly due to the electrical neutrality of its chemical structure. This trait enables PNA probes to be more efficient and useful in applying to FISH (fluorescent in situ hybridization) even at low concentrations. Hybridization occurs fast (within a couple of hours) and background noise is reduced significantly. PNA Bio offers telomere, centromere , and CAG repeat probes as catalog items. If you need other target specific probes, we can provide a custom PNA probe synthesis service. TelC is C-rich a telomere probe for a leading strand (repeats of TAACCC) and TelG is a G-rich telomere probe for lagging strand (repeats of TTAGGG). Both TelC and TelG PNA telomere probes work with human, mouse, and rat chromosomes. CENPB probe is a binding site for centromere protein B (CENP-B), one of the major centromere-specific proteins. The probe sequence is ATTCGTTGGAAACGGGA, and it stains minor satellite of all human and mouse centromere except the Y chromosome. Cent probe is specific for human alpha satellite centromere and does not react to the mouse.
The sequence of the probe is AAACTAGACAGAAGCAT. Order F1001 TelC-FAM C-rich telomere probe,FAM labeled 5 nmole F1002 TelC-Cy3 C-rich telomere probe,Cy3 labeled 5 nmole F1003 TelC-Cy5 C-rich telomere probe, Cy5 labeled 5 nmole F1004 TelC-Alexa488 C-rich telomere probe,Alexa Fluor 488 labeled 5 nmole F1005 TelG-FAM G-rich telomere probe,FAM labeled 5 nmole F1006 TelG-Cy3 G-rich telomere probe,Cy3 labeled 5 nmole F1007 TelG-Cy5 G-rich telomere probe,Cy5 labeled 5 nmole F1008 TelG-Alexa488 G-rich telomere probe,Alexa Fluor 488 labeled 5 nmole F1009 TelC-FITC C-rich telomere probe,FITC labeled 5 nmole F1010 TelG-FITC G-rich telomere probe,FITC labeled 5 nmole F1013 TelC-Alexa647 C-rich telomere probe, Alexa Fluor 647 labeled 5 nmole F1014 TelG-Alexa647 G-rich telomere probe,Alexa Fluor 647 labeled 5 nmole F1020 aTelC-Alexa488 TelC probe for arthropods,Alexa Fluor 488 labeled 5 nmole F2001 TelC-Biotin C-rich telomere probe,Biotin labeled 5 nmole F2002 TelG-Biotin G-rich telomere probe, Biotin labeled 5 nmole F3001 CENPB-FAM Centromere probe,FAM labeled 5 nmole F3002 CENPB-Cy3 Centromere probe,Cy3 labeled 5 nmole F3004 CENPB-Alexa488 Centromere probe,Alexa Fluor 488 labeled 5 nmole F3005 CENPB-Cy5 Centromere probe,Cy5 labeled 5 nmole F3008 CENPB-Biotin Centromere probe,Biotin labeled 5 nmole F3009 CENPBR-Cy3 Reverse complement of CENPB probe,Cy3 labeled 5 nmole F3003 CENT-Cy3 Centromere probe,Cy3 labeled 5 nmole F3006 CENT-FAM Centromere probe,FAM labeled 5 nmole F3007 CENT-RC-A488 Reverse complement of CENT probe, Alexa488 labeled 5 nmole F5001 (CAG)5-Cy3 CAG repeats,Cy3 labeled 5 nmole F5002 (CAG)-Cy5 CAG repeats,Cy5 labeled 5 nmole |